In March of 2010, a study was conducted by researchers Shii, Nakagawa, Yoshimi, Katsuta, Oda and Nakamura from the Research & Development Center of Santen Pharmaceutical Company in Nara, Japan and published in the Biological & Pharmaceutical Bulletin. This study focused on the use of Cyclosporine A (CyA) to treat allergic conjunctivitis. Cyclosporine is an immunosuppressant medication commonly used to treat patients who have received organ transplants. Cyclosporine eye drops have been used to treat pets, such as dogs and cats, with allergies. However, the use of cyclosporine to treat allergic conjunctivitis in humans hasn't been widely studied. Restasis is a cyclosporine product that has been used in humans, but its indication has been for dry eyes. The researchers in this study sought to study CyA specifically for allergic conjunctivitis.In the study, researchers injected guinea pigs with a mixture of ovalbumin (OVA) and Freund's complete adjuvant (FCA), which are just chemicals that induce an allergic reaction. The guinea pigs expressed swelling and discharge from the eyes, suggesting the allergic response had taken hold. After six hours, the researchers used the CyA eye drops on the guinea pigs, which produced a decrease in discharge from the eye. However, CyA did not significantly decrease the swelling.
CyA did inhibit infiltration of white blood cells and fluid in the later stage of the allergic reaction. The researchers have concluded that CyA is effective in decrease late-stage symptoms, but does not alleviate symptoms related to the early-phase of the reaction. With the other medications out there, like anti-histamines and mast cell stabilizers, that work in both the early and late-stage phases of the inflammatory response, it may be better to just skip this one.
For more information about the history of CyA Click Here
For more information about Atopica, an ophthalmic CyA for animals Click Here
For more information about Restasis Click Here
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